Pharmacology assignment Example | Topics and Well Written Essays - 2500 words

Pharmacology - Assignment Example The effect of the new drug on the action of warfarin will be investigated in 12 healthy participants. The investigation is based on an open label study that would utilize a multiple dose design. To analyze the interaction between the two drugs in terms of the way JP234 would induce the metabolism of a single dose of warfarin, both R and S enantiomers were initiated through the CYP450 metabolic pathway. The study will be done based on the assumption that the new drug has been studied in vivo whereby in vitro metabolic studies will be consulted in determining whether JP234 is a substrate or an inhibitor the enzymes involved in the metabolism of warfarin. The study results will help in determining any possible interaction, such as whether PJ234 inhibits or induces the metabolism of warfarin. The mode of warfarin action in this case is based on its impact on the synthesis of vitamin K. The study will thus be able to portray the impact of drug interaction after eliminating warfarin. This will be considered from the results obtained from the group in which only the PJ234 is administered, as compared to the group whereby both the PJ234 and warfarin drugs are administered. JP234 is well tolerated during clinical trials and there is no contradiction associated with it. The drug when administered is effective in doses of 50, 75 or 100mg once daily. The drug is metabolized in the liver and has a half life of about 24 hours. In vitro studies indicate that the drug can induce CYP2C9. Patients with chronic atrial fibrillation should be anticoagulated to hinder thromboembolism from taking place (Goodman, 2005). Patient taking JP234 are recommended to take warfarin that is partly metabolized by CYP2C9. JP234 is an antiarrhythmic drug and is usually excreted in the liver just the same as warfarin. The PJ234 drug is considered an inducer of CYP2C9 which